Phosphoinositide 3-kinase controls early and late events in mammalian cell division.
نویسندگان
چکیده
Phosphoinositide 3-kinase (PI3K) plays a crucial role in triggering cell division. To initiate this process, PI3K induces two distinct routes, of which one promotes cell growth and the other regulates cyclin-dependent kinases. Fine-tuned PI3K regulation is also required for later cell cycle phases. Here, we review the multiple points at which PI3K controls cell division and discuss its impact on human cancer.
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عنوان ژورنال:
- The EMBO journal
دوره 25 4 شماره
صفحات -
تاریخ انتشار 2006